1m3u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1m3u.gif|left|200px]]
[[Image:1m3u.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1m3u |SIZE=350|CAPTION= <scene name='initialview01'>1m3u</scene>, resolution 1.800&Aring;
+
The line below this paragraph, containing "STRUCTURE_1m3u", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=KPL:KETOPANTOATE'>KPL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-methyl-2-oxobutanoate_hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.11 2.1.2.11] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= PANB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1m3u| PDB=1m3u | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m3u OCA], [http://www.ebi.ac.uk/pdbsum/1m3u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m3u RCSB]</span>
+
-
}}
+
'''Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate'''
'''Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate'''
Line 35: Line 32:
[[Category: Smith, A G.]]
[[Category: Smith, A G.]]
[[Category: Witty, M.]]
[[Category: Witty, M.]]
-
[[Category: beta-alpha-barrel]]
+
[[Category: Beta-alpha-barrel]]
-
[[Category: decamer]]
+
[[Category: Decamer]]
-
[[Category: ketopantoate]]
+
[[Category: Ketopantoate]]
-
[[Category: selenomethionine mad]]
+
[[Category: Selenomethionine mad]]
-
[[Category: tim-barrel]]
+
[[Category: Tim-barrel]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:35:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:51 2008''
+

Revision as of 21:35, 2 May 2008

Image:1m3u.gif

Template:STRUCTURE 1m3u

Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate


Overview

We report the crystal structure of E. coli ketopantoate hydroxymethyltransferase (KPHMT) at 1.9 A resolution, in complex with its product, ketopantoate. KPHMT catalyzes the first step in the biosynthesis of pantothenate (vitamin B(5)), the precursor of coenzyme A and the acyl carrier protein cofactor. The structure of the decameric enzyme was solved by multiwavelength anomalous dispersion to locate 160 selenomethionine sites and phase 560 kDa of protein, making it the largest structure solved by this approach. KPHMT adopts the (betaalpha)(8) barrel fold and is a member of the phosphoenolpyruvate/pyruvate superfamily. The active site contains a ketopantoate bidentately coordinated to Mg(2+). Similar binding is likely for the substrate, alpha-ketoisovalerate, orienting the C3 for deprotonation.

About this Structure

1M3U is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites., von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C, Structure. 2003 Aug;11(8):985-96. PMID:12906829 Page seeded by OCA on Sat May 3 00:35:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m3u"
Personal tools