1p0o
From Proteopedia
(Difference between revisions)
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==HP (2-20) substitution of Trp for Gln and Asp at position 17 and 19 MODIFICATION IN SDS-D25 MICELLES== | ==HP (2-20) substitution of Trp for Gln and Asp at position 17 and 19 MODIFICATION IN SDS-D25 MICELLES== | ||
| - | <StructureSection load='1p0o' size='340' side='right'caption='[[1p0o | + | <StructureSection load='1p0o' size='340' side='right'caption='[[1p0o]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1p0o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P0O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1p0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P0O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0o OCA], [https://pdbe.org/1p0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p0o RCSB], [https://www.ebi.ac.uk/pdbsum/1p0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p0o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0o OCA], [https://pdbe.org/1p0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p0o RCSB], [https://www.ebi.ac.uk/pdbsum/1p0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p0o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RL1_HELPY RL1_HELPY] Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity).[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318] Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E.coli and B.megaterium and modest antifungal activities. Has no effect on H.pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria.[HAMAP-Rule:MF_01318] | |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Helicobacter pylori J99]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Harm | + | [[Category: Harm KS]] |
| - | [[Category: Kim | + | [[Category: Kim YM]] |
| - | [[Category: Lee | + | [[Category: Lee DG]] |
| - | [[Category: Lee | + | [[Category: Lee KH]] |
| - | [[Category: Park | + | [[Category: Park YK]] |
| - | + | ||
| - | + | ||
Revision as of 10:29, 16 August 2023
HP (2-20) substitution of Trp for Gln and Asp at position 17 and 19 MODIFICATION IN SDS-D25 MICELLES
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