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2ky3
From Proteopedia
(Difference between revisions)
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==Solution structure of GS-alfa-Ktx5.4 synthetic scorpion like== | ==Solution structure of GS-alfa-Ktx5.4 synthetic scorpion like== | ||
| - | <StructureSection load='2ky3' size='340' side='right'caption='[[2ky3 | + | <StructureSection load='2ky3' size='340' side='right'caption='[[2ky3]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ky3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ky3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KY3 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ky3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ky3 OCA], [https://pdbe.org/2ky3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ky3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ky3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ky3 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ky3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ky3 OCA], [https://pdbe.org/2ky3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ky3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ky3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ky3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buthus tamalus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Castro, L Brieba-De]] | ||
| - | [[Category: Ramirez-Cordero, B E]] | ||
| - | [[Category: Rio-Portilla, F Del]] | ||
| - | [[Category: Aktx5 4]] | ||
| - | [[Category: Alpha helix]] | ||
| - | [[Category: Alpha/beta scaffold]] | ||
| - | [[Category: Beta sheet]] | ||
| - | [[Category: Gs-alpha-ktx5 4]] | ||
[[Category: Mesobuthus tamulus]] | [[Category: Mesobuthus tamulus]] | ||
| - | [[Category: | + | [[Category: Brieba-De Castro L]] |
| - | [[Category: | + | [[Category: Del Rio-Portilla F]] |
| - | [[Category: | + | [[Category: Ramirez-Cordero BE]] |
Revision as of 10:35, 16 August 2023
Solution structure of GS-alfa-Ktx5.4 synthetic scorpion like
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