2x7h
From Proteopedia
(Difference between revisions)
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<StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Chaikuad | + | [[Category: Chaikuad A]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Niesen F]] |
| - | [[Category: Niesen | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Shafqat N]] |
| - | [[Category: Shafqat | + | [[Category: Smee C]] |
| - | [[Category: Smee | + | [[Category: Ugochukwu E]] |
| - | [[Category: Ugochukwu | + | [[Category: Vollmar M]] |
| - | [[Category: Vollmar | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yue WW]] |
| - | [[Category: Yue | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
Current revision
Crystal structure of the human MGC45594 gene product in complex with fenoprofen
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bountra C | Chaikuad A | Edwards A | Niesen F | Oppermann U | Pike ACW | Shafqat N | Smee C | Ugochukwu E | Vollmar M | Weigelt J | Yue WW | Von Delft F
