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5hnm

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Current revision (10:48, 16 August 2023) (edit) (undo)
 
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<StructureSection load='5hnm' size='340' side='right'caption='[[5hnm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5hnm' size='340' side='right'caption='[[5hnm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hnm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HNM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hnm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HNM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vanYB, EF_2297 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnm OCA], [https://pdbe.org/5hnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hnm RCSB], [https://www.ebi.ac.uk/pdbsum/5hnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnm OCA], [http://pdbe.org/5hnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hnm RCSB], [http://www.ebi.ac.uk/pdbsum/5hnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VANY_ENTFA VANY_ENTFA]] Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams.
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[https://www.uniprot.org/uniprot/VANY_ENTFA VANY_ENTFA] Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Entfa]]
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[[Category: Enterococcus faecalis V583]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
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[[Category: Anderson WF]]
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[[Category: Anderson, W F]]
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[[Category: Chun J]]
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[[Category: Structural genomic]]
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[[Category: Courvalin P]]
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[[Category: Chun, J]]
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[[Category: Di Leo R]]
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[[Category: Courvalin, P]]
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[[Category: Evdokimova E]]
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[[Category: Evdokimova, E]]
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[[Category: Savchenko A]]
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[[Category: Leo, R Di]]
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[[Category: Stogios PJ]]
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[[Category: Savchenko, A]]
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[[Category: Wawrzak Z]]
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[[Category: Stogios, P J]]
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[[Category: Yim V]]
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[[Category: Wawrzak, Z]]
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[[Category: Yim, V]]
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[[Category: Alpha+beta protein]]
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[[Category: Antibiotic resistance]]
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[[Category: Csgid]]
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[[Category: Hedgehog/dd-peptidase fold]]
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[[Category: Hydrolase]]
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[[Category: Merops m15b subfamily]]
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[[Category: Metallopeptidase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Vancomycin resistance]]
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[[Category: Zn2+-dependent]]
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Current revision

Crystal structure of vancomycin resistance D,D-pentapeptidase VanY E175A mutant from VanB-type resistance cassette in complex with Zn(II)

PDB ID 5hnm

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