This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5hob
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5hob' size='340' side='right'caption='[[5hob]], [[Resolution|resolution]] 1.22Å' scene=''> | <StructureSection load='5hob' size='340' side='right'caption='[[5hob]], [[Resolution|resolution]] 1.22Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hob]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5hob]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HOB FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.220013Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hob OCA], [https://pdbe.org/5hob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hob RCSB], [https://www.ebi.ac.uk/pdbsum/5hob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hob ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> |
==See Also== | ==See Also== | ||
| Line 18: | Line 17: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Coutandin | + | [[Category: Coutandin D]] |
| - | [[Category: Dotsch | + | [[Category: Dotsch V]] |
| - | [[Category: Knapp | + | [[Category: Knapp S]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Mathea | + | [[Category: Mathea S]] |
| - | [[Category: Salah | + | [[Category: Salah E]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
p73 homo-tetramerization domain mutant I
| |||||||||||
Categories: Homo sapiens | Large Structures | Coutandin D | Dotsch V | Knapp S | Krojer T | Mathea S | Salah E
