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5hod

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Current revision (10:48, 16 August 2023) (edit) (undo)
 
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<StructureSection load='5hod' size='340' side='right'caption='[[5hod]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
<StructureSection load='5hod' size='340' side='right'caption='[[5hod]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HOD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HOD FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LHX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.682&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hod OCA], [http://pdbe.org/5hod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hod RCSB], [http://www.ebi.ac.uk/pdbsum/5hod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hod ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hod OCA], [https://pdbe.org/5hod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hod RCSB], [https://www.ebi.ac.uk/pdbsum/5hod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hod ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN]] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Pituitary stalk interruption syndrome;Short stature - pituitary and cerebellar defects - small sella turcica. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.<ref>PMID:11567216</ref>
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[https://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Pituitary stalk interruption syndrome;Short stature - pituitary and cerebellar defects - small sella turcica. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.<ref>PMID:11567216</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
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[https://www.uniprot.org/uniprot/LHX4_HUMAN LHX4_HUMAN] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Morgunova, E]]
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[[Category: Morgunova E]]
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[[Category: Popov, A]]
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[[Category: Popov A]]
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[[Category: Taipale, J]]
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[[Category: Taipale J]]
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[[Category: Yin, Y]]
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[[Category: Yin Y]]
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[[Category: Complex with dna]]
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[[Category: Dimer]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Structure of LHX4 transcription factor complexed with DNA

PDB ID 5hod

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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