1m51

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[[Image:1m51.gif|left|200px]]
[[Image:1m51.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1m51 |SIZE=350|CAPTION= <scene name='initialview01'>1m51</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1m51", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TSX:N-[4-(1-ALLYL-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL)-PHENYL]-ACETAMIDE'>TSX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PCK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1m51| PDB=1m51 | SCENE= }}
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|RELATEDENTRY=[[1khb|1KHB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m51 OCA], [http://www.ebi.ac.uk/pdbsum/1m51 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m51 RCSB]</span>
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}}
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'''PEPCK complex with a GTP-competitive inhibitor'''
'''PEPCK complex with a GTP-competitive inhibitor'''
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X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines., Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14552798 14552798]
X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines., Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14552798 14552798]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Dunten, P.]]
[[Category: Dunten, P.]]
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[[Category: Wang, P.]]
[[Category: Wang, P.]]
[[Category: Wertheimer, S J.]]
[[Category: Wertheimer, S J.]]
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[[Category: gluconeogenesis]]
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[[Category: Gluconeogenesis]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: xanthine]]
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[[Category: Xanthine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:21 2008''
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Revision as of 21:38, 2 May 2008

Image:1m51.gif

Template:STRUCTURE 1m51

PEPCK complex with a GTP-competitive inhibitor


Contents

Overview

The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented.

Disease

Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[261680]

About this Structure

1M51 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines., Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:14552798 Page seeded by OCA on Sat May 3 00:38:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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