P63

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Current revision (07:41, 21 August 2023) (edit) (undo)
 
Line 26: Line 26:
**[[2rmn]] – hP63 - human - NMR<br />
**[[2rmn]] – hP63 - human - NMR<br />
**[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br />
**[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br />
 +
**[[7z71]], [[7z7e]] – hP63 + darpin<br />
*p63 tetramerization domain (397-455)
*p63 tetramerization domain (397-455)
Line 31: Line 32:
**[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br />
**[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br />
**[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br />
**[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br />
 +
**[[7z73]] – hP63 + darpin<br />
*p63 C terminal domain (501-575)
*p63 C terminal domain (501-575)
Line 40: Line 42:
**[[2y9t]] – hP63 - NMR<br />
**[[2y9t]] – hP63 - NMR<br />
**[[2y9u]] – hP63 (mutant)<br />
**[[2y9u]] – hP63 (mutant)<br />
 +
**[[7z72]] – hP63 + darpin<br />
**[[5n2o]] – P63 (mutant) - mouse<br />
**[[5n2o]] – P63 (mutant) - mouse<br />
}}
}}

Current revision

P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code 3us0)

Drag the structure with the mouse to rotate

3D Structures of P63

Updated on 21-August-2023

References

  1. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:http://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
  2. Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
  3. Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
  4. Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:http://dx.doi.org/10.4161/cc.6.3.3792
  5. Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:http://dx.doi.org/10.1002/jcp.20829

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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