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1m5o

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[[Image:1m5o.gif|left|200px]]
[[Image:1m5o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1m5o |SIZE=350|CAPTION= <scene name='initialview01'>1m5o</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1m5o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=AVC:ADENOSINE-5&#39;-MONOPHOSPHATE-2&#39;,3&#39;-VANADATE'>AVC</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= SNRPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1m5o| PDB=1m5o | SCENE= }}
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|RELATEDENTRY=[[1m5k|1M5K]], [[1m5p|1M5P]], [[1m5v|1M5V]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m5o OCA], [http://www.ebi.ac.uk/pdbsum/1m5o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m5o RCSB]</span>
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}}
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'''Transition State Stabilization by a Catalytic RNA'''
'''Transition State Stabilization by a Catalytic RNA'''
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[[Category: Rupert, P B.]]
[[Category: Rupert, P B.]]
[[Category: Sigurdsson, S T.]]
[[Category: Sigurdsson, S T.]]
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[[Category: catalytic rna]]
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[[Category: Catalytic rna]]
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[[Category: hairpin ribozyme]]
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[[Category: Hairpin ribozyme]]
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[[Category: transition state mimic]]
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[[Category: Transition state mimic]]
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[[Category: u1a rna binding protein]]
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[[Category: U1a rna binding protein]]
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[[Category: vandate]]
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[[Category: Vandate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:39:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:36 2008''
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Revision as of 21:39, 2 May 2008

Image:1m5o.gif

Template:STRUCTURE 1m5o

Transition State Stabilization by a Catalytic RNA


Overview

The hairpin ribozyme catalyzes sequence-specific cleavage of RNA through transesterification of the scissile phosphate. Vanadate has previously been used as a transition state mimic of protein enzymes that catalyze the same reaction. Comparison of the 2.2 angstrom resolution structure of a vanadate-hairpin ribozyme complex with structures of precursor and product complexes reveals a rigid active site that makes more hydrogen bonds to the transition state than to the precursor or product. Because of the paucity of RNA functional groups capable of general acid-base or electrostatic catalysis, transition state stabilization is likely to be an important catalytic strategy for ribozymes.

About this Structure

1M5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Transition state stabilization by a catalytic RNA., Rupert PB, Massey AP, Sigurdsson ST, Ferre-D'Amare AR, Science. 2002 Nov 15;298(5597):1421-4. Epub 2002 Oct 10. PMID:12376595 Page seeded by OCA on Sat May 3 00:39:56 2008

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OCA

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