1m5q

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[[Image:1m5q.gif|left|200px]]
[[Image:1m5q.gif|left|200px]]
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{{Structure
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|PDB= 1m5q |SIZE=350|CAPTION= <scene name='initialview01'>1m5q</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1m5q", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= SmAP3 gene (Pae2122) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=13773 Pyrobaculum aerophilum])
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|DOMAIN=
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{{STRUCTURE_1m5q| PDB=1m5q | SCENE= }}
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|RELATEDENTRY=[[1i8f|1I8F]], [[1jbm|1JBM]], [[1i4k|1I4K]], [[1d3b|1D3B]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m5q OCA], [http://www.ebi.ac.uk/pdbsum/1m5q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m5q RCSB]</span>
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'''Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum'''
'''Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum'''
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[[Category: Phillips, M.]]
[[Category: Phillips, M.]]
[[Category: 14-mer]]
[[Category: 14-mer]]
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[[Category: b-sheet toroid]]
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[[Category: B-sheet toroid]]
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[[Category: cadmium-binding site]]
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[[Category: Cadmium-binding site]]
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[[Category: ob-like fold]]
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[[Category: Ob-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:40:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:38 2008''
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Revision as of 21:40, 2 May 2008

Image:1m5q.gif

Template:STRUCTURE 1m5q

Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum


Overview

To better understand the roles of Sm proteins in forming the cores of many RNA-processing ribonucleoproteins, we determined the crystal structure of an atypical Sm-like archaeal protein (SmAP3) in which the conserved Sm domain is augmented by a previously uncharacterized, mixed alpha/beta C-terminal domain. The structure reveals an unexpected SmAP3 14-mer that is perforated by a cylindrical pore and is bound to 14 cadmium (Cd(2+)) ions. Individual heptamers adopt either "apical" or "equatorial" conformations that chelate Cd(2+) differently. SmAP3 forms supraheptameric oligomers (SmAP3)(n = 7,14,28) in solution, and assembly of the asymmetric 14-mer is modulated by differential divalent cation-binding in apical and equatorial subunits. Phylogenetic and sequence analyses substantiate SmAP3s as a unique subset of SmAPs. These results distinguish SmAP3s from other Sm proteins and provide a model for the structure and properties of Sm proteins >100 residues in length, e.g., several human Sm proteins.

About this Structure

1M5Q is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure and assembly of an augmented Sm-like archaeal protein 14-mer., Mura C, Phillips M, Kozhukhovsky A, Eisenberg D, Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4539-44. Epub 2003 Mar 31. PMID:12668760 Page seeded by OCA on Sat May 3 00:40:01 2008

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