8aqf
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND LEI-515== | |
| - | + | <StructureSection load='8aqf' size='340' side='right'caption='[[8aqf]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8aqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUX:1-[(~{R})-[2-chloranyl-4-[(2~{S},3~{S})-4-(3-chlorophenyl)-2,3-dimethyl-piperazin-1-yl]carbonyl-phenyl]sulfinyl]-3,3-bis(fluoranyl)pentan-2-one'>NUX</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqf OCA], [https://pdbe.org/8aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqf RCSB], [https://www.ebi.ac.uk/pdbsum/8aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqf ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Amedi A]] |
| - | [[Category: | + | [[Category: Benz J]] |
| - | [[Category: | + | [[Category: Boeckel C]] |
| - | [[Category: | + | [[Category: Collin L]] |
| - | [[Category: | + | [[Category: Deng H]] |
| - | [[Category: | + | [[Category: Driever W]] |
| - | [[Category: | + | [[Category: Florea B]] |
| - | [[Category: | + | [[Category: Grether U]] |
| - | [[Category: | + | [[Category: Heitman L]] |
| - | [[Category: | + | [[Category: Hohmann A]] |
| - | [[Category: | + | [[Category: Huizenga M]] |
| - | [[Category: | + | [[Category: Janssen A]] |
| - | [[Category: | + | [[Category: Jiang M]] |
| - | [[Category: Van | + | [[Category: Lam TW]] |
| - | [[Category: | + | [[Category: Mohr F]] |
| - | [[Category: | + | [[Category: Pacher P]] |
| - | [[Category: | + | [[Category: Paloczi J]] |
| + | [[Category: Pavlovic A]] | ||
| + | [[Category: Ruf I]] | ||
| + | [[Category: Rutjes H]] | ||
| + | [[Category: Stevens F]] | ||
| + | [[Category: Wirt J]] | ||
| + | [[Category: Wittwer M]] | ||
| + | [[Category: Van der Berg R]] | ||
| + | [[Category: Van der Stelt M]] | ||
| + | [[Category: Van der Vliet D]] | ||
| + | [[Category: Van der Wel T]] | ||
Current revision
CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND LEI-515
| |||||||||||
Categories: Homo sapiens | Large Structures | Amedi A | Benz J | Boeckel C | Collin L | Deng H | Driever W | Florea B | Grether U | Heitman L | Hohmann A | Huizenga M | Janssen A | Jiang M | Lam TW | Mohr F | Pacher P | Paloczi J | Pavlovic A | Ruf I | Rutjes H | Stevens F | Wirt J | Wittwer M | Van der Berg R | Van der Stelt M | Van der Vliet D | Van der Wel T
