8b12

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'''Unreleased structure'''
 
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The entry 8b12 is ON HOLD until Paper Publication
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==cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A and CsoS2 co-expression (T = 9)==
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<StructureSection load='8b12' size='340' side='right'caption='[[8b12]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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Authors: Ni, T., Jiang, Q., Liu, L.N., Zhang, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8b12]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Halothiobacillus_neapolitanus Halothiobacillus neapolitanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B12 FirstGlance]. <br>
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Description: cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A and CsoS2 co-expression (T = 9)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b12 OCA], [https://pdbe.org/8b12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b12 RCSB], [https://www.ebi.ac.uk/pdbsum/8b12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b12 ProSAT]</span></td></tr>
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[[Category: Jiang, Q]]
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</table>
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[[Category: Liu, L.N]]
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== Function ==
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[[Category: Ni, T]]
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[https://www.uniprot.org/uniprot/CSOSA_HALNC CSOSA_HALNC] The major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered (PubMed:7934888, PubMed:16535117). Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome (PubMed:17518518). The shell probably limits the diffusion of CO(2) into and out of the carboxysome (Probable). Molecular modeling shows the central pore of this protein is selectively permeable to anions such as HCO(3) rather than CO(2) or O(2) (Probable). There are estimated to be 2970 CsoS1A/CsoS1C proteins per carboxysome (the proteins differ by only 1 residue) (Ref.5).<ref>PMID:16535117</ref> <ref>PMID:17518518</ref> <ref>PMID:7934888</ref> <ref>PMID:22184212</ref> <ref>PMID:18258595</ref> <ref>PMID:30193460</ref> Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.<ref>PMID:25826651</ref> <ref>PMID:33116131</ref>
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[[Category: Zhang, P]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Halothiobacillus neapolitanus]]
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[[Category: Large Structures]]
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[[Category: Jiang Q]]
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[[Category: Liu LN]]
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[[Category: Ni T]]
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[[Category: Zhang P]]

Revision as of 05:52, 23 August 2023

cryo-EM structure of carboxysomal mini-shell: icosahedral assembly from CsoS4A/1A and CsoS2 co-expression (T = 9)

PDB ID 8b12

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