1m6b

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[[Image:1m6b.jpg|left|200px]]
[[Image:1m6b.jpg|left|200px]]
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{{Structure
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|PDB= 1m6b |SIZE=350|CAPTION= <scene name='initialview01'>1m6b</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1m6b", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1m6b| PDB=1m6b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6b OCA], [http://www.ebi.ac.uk/pdbsum/1m6b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m6b RCSB]</span>
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}}
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'''Structure of the HER3 (ERBB3) Extracellular Domain'''
'''Structure of the HER3 (ERBB3) Extracellular Domain'''
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[[Category: Cho, H S.]]
[[Category: Cho, H S.]]
[[Category: Leahy, D J.]]
[[Category: Leahy, D J.]]
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[[Category: cell surface receptor]]
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[[Category: Cell surface receptor]]
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[[Category: immunity]]
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[[Category: Immunity]]
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[[Category: tyrosine kinase]]
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[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:41:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:56 2008''
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Revision as of 21:41, 2 May 2008

Image:1m6b.jpg

Template:STRUCTURE 1m6b

Structure of the HER3 (ERBB3) Extracellular Domain


Overview

We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.

About this Structure

1M6B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198 Page seeded by OCA on Sat May 3 00:41:13 2008

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OCA

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