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8jfd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 8 (B21594), NADPH and dUMP== | |
| - | + | <StructureSection load='8jfd' size='340' side='right'caption='[[8jfd]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JFD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=U8Y:3-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic+acid'>U8Y</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jfd OCA], [https://pdbe.org/8jfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jfd RCSB], [https://www.ebi.ac.uk/pdbsum/8jfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jfd ProSAT]</span></td></tr> |
| - | [[Category: Hoarau | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Vanichtanankul | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Plasmodium falciparum]] |
| + | [[Category: Hoarau M]] | ||
| + | [[Category: Kamchonwongpaisan S]] | ||
| + | [[Category: Saepua S]] | ||
| + | [[Category: Saeyang T]] | ||
| + | [[Category: Thongpanchang C]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Vitsupakorn D]] | ||
| + | [[Category: Yuthavong Y]] | ||
Current revision
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 8 (B21594), NADPH and dUMP
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