1m6d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1m6d.gif|left|200px]]
[[Image:1m6d.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1m6d |SIZE=350|CAPTION= <scene name='initialview01'>1m6d</scene>, resolution 1.7&Aring;
+
The line below this paragraph, containing "STRUCTURE_1m6d", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MYP:4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC+ACID+[1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE'>MYP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_F Cathepsin F], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.41 3.4.22.41] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CATF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1m6d| PDB=1m6d | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6d OCA], [http://www.ebi.ac.uk/pdbsum/1m6d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m6d RCSB]</span>
+
-
}}
+
'''Crystal structure of human cathepsin F'''
'''Crystal structure of human cathepsin F'''
Line 29: Line 26:
[[Category: Palmer, J T.]]
[[Category: Palmer, J T.]]
[[Category: Somoza, J R.]]
[[Category: Somoza, J R.]]
-
[[Category: papain family cysteine protease]]
+
[[Category: Papain family cysteine protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:41:23 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:56 2008''
+

Revision as of 21:41, 2 May 2008

Image:1m6d.gif

Template:STRUCTURE 1m6d

Crystal structure of human cathepsin F


Overview

Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.

About this Structure

1M6D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators., Somoza JR, Palmer JT, Ho JD, J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:12225749 Page seeded by OCA on Sat May 3 00:41:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m6d"
Personal tools