1qz1

From Proteopedia

(Difference between revisions)

Revision as of 05:58, 23 August 2023

Crystal Structure of the Ig 1-2-3 fragment of NCAM

Structural highlights

1qz1 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NCAM1_RAT This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM molecules) binding. NCAM plays a key role in neural development, regeneration, and synaptic plasticity, including learning and memory consolidation. The crystal structure of a fragment comprising the three N-terminal Ig modules of rat NCAM has been determined to 2.0 A resolution. Based on crystallographic data and biological experiments we present a novel model for NCAM homophilic binding. The Ig1 and Ig2 modules mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), whereas the Ig3 module mediates interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through simultaneous binding to the Ig1 and Ig2 modules. This arrangement results in two perpendicular zippers forming a double zipper-like NCAM adhesion complex.

Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.,Soroka V, Kolkova K, Kastrup JS, Diederichs K, Breed J, Kiselyov VV, Poulsen FM, Larsen IK, Welte W, Berezin V, Bock E, Kasper C Structure. 2003 Oct;11(10):1291-301. PMID:14527396^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Soroka V, Kolkova K, Kastrup JS, Diederichs K, Breed J, Kiselyov VV, Poulsen FM, Larsen IK, Welte W, Berezin V, Bock E, Kasper C. Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. Structure. 2003 Oct;11(10):1291-301. PMID:14527396

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qz1"

@@ Line 3: / Line 3: @@
 <StructureSection load='1qz1' size='340' side='right'caption='[[1qz1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1qz1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1QZ1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1qz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ1 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ncm|2ncm]], [[3ncm|3ncm]], [[1epf|1epf]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz1 OCA], [https://pdbe.org/1qz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz1 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz1 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1qz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz1 OCA], [http://pdbe.org/1qz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qz1 RCSB], [http://www.ebi.ac.uk/pdbsum/1qz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz1 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT]] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
+[https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Berezin, V]]
+[[Category: Rattus norvegicus]]
-[[Category: Bock, E]]
+[[Category: Berezin V]]
-[[Category: Breed, J]]
+[[Category: Bock E]]
-[[Category: Diederichs, K]]
+[[Category: Breed J]]
-[[Category: Kasper, C]]
+[[Category: Diederichs K]]
-[[Category: Kastrup, J S]]
+[[Category: Kasper C]]
-[[Category: Kiselyov, V V]]
+[[Category: Kastrup JS]]
-[[Category: Kolkova, K]]
+[[Category: Kiselyov VV]]
-[[Category: Larsen, I K]]
+[[Category: Kolkova K]]
-[[Category: Poulsen, F M]]
+[[Category: Larsen IK]]
-[[Category: Soroka, V]]
+[[Category: Poulsen FM]]
-[[Category: Welte, W]]
+[[Category: Soroka V]]
-[[Category: Cell adhesion]]
+[[Category: Welte W]]
-[[Category: Ig module]]
-[[Category: Ncam]]

1qz1

From Proteopedia

Revision as of 05:58, 23 August 2023

Crystal Structure of the Ig 1-2-3 fragment of NCAM

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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