1m73

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[[Image:1m73.gif|left|200px]]
[[Image:1m73.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1m73 |SIZE=350|CAPTION= <scene name='initialview01'>1m73</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1m73", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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|GENE=
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{{STRUCTURE_1m73| PDB=1m73 | SCENE= }}
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|RELATEDENTRY=[[1ula|1ULA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m73 OCA], [http://www.ebi.ac.uk/pdbsum/1m73 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m73 RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN PNP AT 2.3A RESOLUTION'''
'''CRYSTAL STRUCTURE OF HUMAN PNP AT 2.3A RESOLUTION'''
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[[Category: Santos, G C.]]
[[Category: Santos, G C.]]
[[Category: Silva, R G.]]
[[Category: Silva, R G.]]
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[[Category: crystallography]]
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[[Category: Crystallography]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: purine nucleoside phosphorylase]]
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[[Category: Purine nucleoside phosphorylase]]
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[[Category: synchrotron]]
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[[Category: Synchrotron]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:43:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:12:16 2008''
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Revision as of 21:43, 2 May 2008

Image:1m73.gif

Template:STRUCTURE 1m73

CRYSTAL STRUCTURE OF HUMAN PNP AT 2.3A RESOLUTION


Overview

Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. In human, PNP is the only route for degradation of deoxyguanosine and genetic deficiency of this enzyme leads to profound T-cell mediated immunosuppression. PNP is therefore a target for inhibitor development aiming at T-cell immune response modulation and its low resolution structure has been used for drug design. Here we report the structure of human PNP solved to 2.3A resolution using synchrotron radiation and cryocrystallographic techniques. This structure allowed a more precise analysis of the active site, generating a more reliable model for substrate binding. The higher resolution data allowed the identification of water molecules in the active site, which suggests binding partners for potential ligands. Furthermore, the present structure may be used in the new structure-based design of PNP inhibitors.

About this Structure

1M73 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution., de Azevedo WF Jr, Canduri F, dos Santos DM, Silva RG, de Oliveira JS, de Carvalho LP, Basso LA, Mendes MA, Palma MS, Santos DS, Biochem Biophys Res Commun. 2003 Aug 29;308(3):545-52. PMID:12914785 Page seeded by OCA on Sat May 3 00:43:04 2008

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