1th6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='1th6' size='340' side='right'caption='[[1th6]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
<StructureSection load='1th6' size='340' side='right'caption='[[1th6]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1th6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TH6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1th6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TH6 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OIN:(1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+(2R)-3-HYDROXY-2-PHENYLPROPANOATE'>OIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.23&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q7a|1q7a]], [[1sv3|1sv3]], [[1tg1|1tg1]], [[1tg4|1tg4]], [[1tgm|1tgm]], [[1ti0|1ti0]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OIN:(1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+(2R)-3-HYDROXY-2-PHENYLPROPANOATE'>OIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1th6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1th6 OCA], [https://pdbe.org/1th6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1th6 RCSB], [https://www.ebi.ac.uk/pdbsum/1th6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1th6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1th6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1th6 OCA], [https://pdbe.org/1th6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1th6 RCSB], [https://www.ebi.ac.uk/pdbsum/1th6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1th6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR]] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
+
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 29: Line 28:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Daboia russellii russellii]]
+
[[Category: Daboia russelii russelii]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Betzel, C]]
+
[[Category: Betzel C]]
-
[[Category: Jabeen, T]]
+
[[Category: Jabeen T]]
-
[[Category: Pal, A]]
+
[[Category: Pal A]]
-
[[Category: Perbandt, M]]
+
[[Category: Perbandt M]]
-
[[Category: Sharma, S]]
+
[[Category: Sharma S]]
-
[[Category: Singh, N]]
+
[[Category: Singh N]]
-
[[Category: Singh, T P]]
+
[[Category: Singh TP]]
-
[[Category: Eicosanoid]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibition]]
+
-
[[Category: Phospholipid]]
+

Revision as of 06:30, 23 August 2023

Crystal structure of phospholipase A2 in complex with atropine at 1.23A resolution

PDB ID 1th6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1th6"
Personal tools