1tp3
From Proteopedia
(Difference between revisions)
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<StructureSection load='1tp3' size='340' side='right'caption='[[1tp3]], [[Resolution|resolution]] 1.99Å' scene=''> | <StructureSection load='1tp3' size='340' side='right'caption='[[1tp3]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1tp3]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1tp3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TP3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tp3 OCA], [https://pdbe.org/1tp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tp3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tp3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Griffin A]] |
| - | [[Category: | + | [[Category: Kovari LC]] |
| - | [[Category: | + | [[Category: Martin P]] |
| - | [[Category: | + | [[Category: Saro D]] |
| - | [[Category: | + | [[Category: Spaller MR]] |
| - | [[Category: | + | [[Category: Vickrey JF]] |
Current revision
PDZ3 domain of PSD-95 protein complexed with KKETPV peptide ligand
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