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1tw9

From Proteopedia

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Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus

Structural highlights

1tw9 is a 8 chain structure with sequence from Heligmosomoides polygyrus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.71Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9NJQ6_HELPZ

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of GST Nu2-2 (HpolGSTN2-2) from the model hookworm nematode Heligmosomoides polygyrus has been solved by the molecular replacement method and refined to a resolution of 1.71 A, providing the first structural data from a class of nematode-specific GSTs. By structural alignment with two Sigma class GSTs, glutathione could be rationally docked into the G-site of the enzyme. By comparing with all mammalian GST classes, a novel, long, and deep cleft was identified at the H-site, providing a potential site for ligand binding. This new GST class may support the establishment of infection parasitic nematodes by passively neutralizing chemical toxins derived from host environment. The structure serves as a starting point for structure-based drug/inhibitor design that would aim to selectively disrupt nematode chemical defenses.

Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus.,Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q Proteins. 2005 Dec 1;61(4):1024-31. PMID:16189827^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q. Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus. Proteins. 2005 Dec 1;61(4):1024-31. PMID:16189827 doi:http://dx.doi.org/10.1002/prot.20649

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tw9"

@@ Line 3: / Line 3: @@
 <StructureSection load='1tw9' size='340' side='right'caption='[[1tw9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1tw9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helpz Helpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TW9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1tw9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Heligmosomoides_polygyrus Heligmosomoides polygyrus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TW9 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw9 OCA], [https://pdbe.org/1tw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tw9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tw9 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tw9 OCA], [https://pdbe.org/1tw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tw9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tw9 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9NJQ6_HELPZ Q9NJQ6_HELPZ]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Helpz]]
+[[Category: Heligmosomoides polygyrus]]
 [[Category: Large Structures]]
-[[Category: Barrett, J]]
+[[Category: Barrett J]]
-[[Category: Brophy, P M]]
+[[Category: Brophy PM]]
-[[Category: Campbell, A M]]
+[[Category: Campbell AM]]
-[[Category: Hao, Q]]
+[[Category: Hao Q]]
-[[Category: Kriksunov, I A]]
+[[Category: Kriksunov IA]]
-[[Category: Liu, Q]]
+[[Category: Liu Q]]
-[[Category: Schuller, D J]]
+[[Category: Schuller DJ]]
-[[Category: Transferase]]

1tw9

From Proteopedia

Current revision

Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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