1u13

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Current revision (06:36, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1u13' size='340' side='right'caption='[[1u13]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='1u13' size='340' side='right'caption='[[1u13]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U13 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U13 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e9x|1e9x]], [[1ea1|1ea1]], [[1h5z|1h5z]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Name=cyp51; OrderedLocusNames=Rv0764c, MT0788, Mb0787c; ORFNames=MTCY369.09c; ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u13 OCA], [https://pdbe.org/1u13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u13 RCSB], [https://www.ebi.ac.uk/pdbsum/1u13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u13 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u13 OCA], [https://pdbe.org/1u13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u13 RCSB], [https://www.ebi.ac.uk/pdbsum/1u13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u13 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CP51_MYCTU CP51_MYCTU]] Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.<ref>PMID:9756611</ref> <ref>PMID:10430874</ref>
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[https://www.uniprot.org/uniprot/CP51_MYCTU CP51_MYCTU] Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.<ref>PMID:9756611</ref> <ref>PMID:10430874</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Kim, Y]]
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[[Category: Kim Y]]
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[[Category: Podust, L M]]
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[[Category: Podust LM]]
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[[Category: Waterman, M R]]
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[[Category: Waterman MR]]
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[[Category: Yermalitskaya, L V]]
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[[Category: Yermalitskaya LV]]
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[[Category: Alpha-beta]]
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[[Category: Heme co-factor]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure analysis of the C37L/C151T/C442A-triple mutant of CYP51 from Mycobacterium tuberculosis

PDB ID 1u13

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OCA

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