1u1y

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Current revision (06:36, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1u1y' size='340' side='right'caption='[[1u1y]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='1u1y' size='340' side='right'caption='[[1u1y]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u1y]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_ms2 Bacteriophage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U1Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u1y]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_MS2 Escherichia phage MS2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U1Y FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq3|1aq3]], [[1aq4|1aq4]], [[1bms|1bms]], [[1zds|1zds]], [[1e6t|1e6t]], [[1e7x|1e7x]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1y OCA], [https://pdbe.org/1u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u1y RCSB], [https://www.ebi.ac.uk/pdbsum/1u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1y OCA], [https://pdbe.org/1u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u1y RCSB], [https://www.ebi.ac.uk/pdbsum/1u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA.
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[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacteriophage ms2]]
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[[Category: Escherichia phage MS2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adams, C J]]
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[[Category: Adams CJ]]
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[[Category: Convery, M A]]
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[[Category: Convery MA]]
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[[Category: Horn, W T]]
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[[Category: Horn WT]]
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[[Category: Liljas, L]]
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[[Category: Liljas L]]
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[[Category: Phillips, S E]]
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[[Category: Phillips SE]]
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[[Category: Stockley, P G]]
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[[Category: Stockley PG]]
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[[Category: Stonehouse, N J]]
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[[Category: Stonehouse NJ]]
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[[Category: Capsid]]
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[[Category: Hairpin]]
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[[Category: Icosahedral virus]]
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[[Category: Levivirus]]
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[[Category: Virus-rna complex]]
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Current revision

Crystal structure of a complex between WT bacteriophage MS2 coat protein and an F5 aptamer RNA stemloop with 2aminopurine substituted at the-10 position

PDB ID 1u1y

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