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1u58

From Proteopedia

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Crystal structure of the murine cytomegalovirus MHC-I homolog m144

Structural highlights

1u58 is a 2 chain structure with sequence from Murid betaherpesvirus 1 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A2Q6L5_MUHVK

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Large DNA viruses of the herpesvirus family produce proteins that mimic host MHC-I molecules as part of their immunoevasive strategy. The m144 glycoprotein, expressed by murine cytomegalovirus, is thought to be an MHC-I homolog whose expression prolongs viral survival in vivo by preventing natural killer cell activation. To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. This structure reveals the canonical features of MHC-I molecules including readily identifiable alpha1, alpha2, and alpha3 domains. A unique disulfide bond links the alpha1 helix to the beta-sheet floor, explaining the known thermal stability of m144. Close juxtaposition of the alpha1 and alpha2 helices and the lack of critical residues that normally contribute to anchoring the peptide N and C termini eliminates peptide binding. A region of 13 amino acid residues, corresponding to the amino-terminal portion of the alpha2 helix, is missing in the electron density map, suggesting an area of structural flexibility that may be involved in ligand binding.

Crystal structure of the murine cytomegalovirus MHC-I homolog m144.,Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH J Mol Biol. 2006 Apr 21;358(1):157-71. Epub 2006 Feb 9. PMID:16500675^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH. Crystal structure of the murine cytomegalovirus MHC-I homolog m144. J Mol Biol. 2006 Apr 21;358(1):157-71. Epub 2006 Feb 9. PMID:16500675 doi:10.1016/j.jmb.2006.01.068

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u58"

@@ Line 3: / Line 3: @@
 <StructureSection load='1u58' size='340' side='right'caption='[[1u58]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1u58]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U58 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U58 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1u58]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_betaherpesvirus_1 Murid betaherpesvirus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U58 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">m144 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10366 MUHV1])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u58 OCA], [http://pdbe.org/1u58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u58 RCSB], [http://www.ebi.ac.uk/pdbsum/1u58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u58 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u58 OCA], [https://pdbe.org/1u58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u58 RCSB], [https://www.ebi.ac.uk/pdbsum/1u58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u58 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A2Q6L5_MUHVK A2Q6L5_MUHVK]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Murid betaherpesvirus 1]]
-[[Category: Muhv1]]
+[[Category: Mus musculus]]
-[[Category: Guan, R]]
+[[Category: Guan R]]
-[[Category: Hicks, A]]
+[[Category: Hicks A]]
-[[Category: Margulies, D H]]
+[[Category: Margulies DH]]
-[[Category: Natarajan, K]]
+[[Category: Natarajan K]]
-[[Category: Robinson, H]]
+[[Category: Robinson H]]
-[[Category: Beta-2m]]
-[[Category: Immune system]]
-[[Category: M144]]
-[[Category: Mcmv]]
-[[Category: Mhc-i homolog]]

1u58

From Proteopedia

Current revision

Crystal structure of the murine cytomegalovirus MHC-I homolog m144

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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