1u9k

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<StructureSection load='1u9k' size='340' side='right'caption='[[1u9k]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='1u9k' size='340' side='right'caption='[[1u9k]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U9K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trem ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9k OCA], [http://pdbe.org/1u9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u9k RCSB], [http://www.ebi.ac.uk/pdbsum/1u9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9k OCA], [https://pdbe.org/1u9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9k RCSB], [https://www.ebi.ac.uk/pdbsum/1u9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TREM1_MOUSE TREM1_MOUSE]] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).
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[https://www.uniprot.org/uniprot/TREM1_MOUSE TREM1_MOUSE] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Debler, E W]]
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[[Category: Debler EW]]
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[[Category: Kelker, M S]]
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[[Category: Kelker MS]]
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[[Category: Wilson, I A]]
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[[Category: Wilson IA]]
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[[Category: Activating receptor]]
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[[Category: Immune system]]
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[[Category: Immune system receptor]]
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[[Category: Innate immunity]]
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[[Category: Trem-1]]
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Revision as of 06:39, 23 August 2023

Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76

PDB ID 1u9k

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