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| | <StructureSection load='1xuq' size='340' side='right'caption='[[1xuq]], [[Resolution|resolution]] 1.80Å' scene=''> | | <StructureSection load='1xuq' size='340' side='right'caption='[[1xuq]], [[Resolution|resolution]] 1.80Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1xuq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XUQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1xuq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xre|1xre]]</div></td></tr>
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sodA1, sodA-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuq OCA], [https://pdbe.org/1xuq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xuq RCSB], [https://www.ebi.ac.uk/pdbsum/1xuq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xuq ProSAT]</span></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuq OCA], [http://pdbe.org/1xuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xuq RCSB], [http://www.ebi.ac.uk/pdbsum/1xuq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xuq ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/SODM1_BACAN SODM1_BACAN]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | + | [https://www.uniprot.org/uniprot/SODM1_BACAN SODM1_BACAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Large Structures]] | |
| - | [[Category: Superoxide dismutase]] | |
| - | [[Category: Blagova, E V]] | |
| - | [[Category: Boucher, I W]] | |
| - | [[Category: Brannigan, J A]] | |
| - | [[Category: Fogg, M J]] | |
| - | [[Category: Levdikov, V M]] | |
| - | [[Category: Wilkinson, A J]] | |
| - | [[Category: Wilson, K S]] | |
| - | [[Category: Ba4499]] | |
| | [[Category: Bacillus anthracis]] | | [[Category: Bacillus anthracis]] |
| - | [[Category: Oxidoreductase]] | + | [[Category: Large Structures]] |
| - | [[Category: Soda-1]] | + | [[Category: Blagova EV]] |
| - | [[Category: Spine]] | + | [[Category: Boucher IW]] |
| | + | [[Category: Brannigan JA]] |
| | + | [[Category: Fogg MJ]] |
| | + | [[Category: Levdikov VM]] |
| | + | [[Category: Wilkinson AJ]] |
| | + | [[Category: Wilson KS]] |
| Structural highlights
Function
SODM1_BACAN Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B. anthracis solved to high resolution are reported. Comparison of their structures reveals that a highly conserved residue near the active centre is substituted in one of the proteins and that this is a characteristic feature of superoxide dismutases from the B. cereus/B. anthracis/B. thuringiensis group of organisms.
Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.,Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ. Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113 doi:http://dx.doi.org/10.1107/S1744309105017380
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