1m8z
From Proteopedia
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'''Crystal Structure Of A Pumilio-Homology Domain''' | '''Crystal Structure Of A Pumilio-Homology Domain''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry | + | 1M8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ib3 1ib3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Wang, X.]] | [[Category: Wang, X.]] | ||
[[Category: Zamore, P D.]] | [[Category: Zamore, P D.]] | ||
| - | [[Category: | + | [[Category: Puf domain]] |
| - | [[Category: | + | [[Category: Pumilio homology domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:46:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:46, 2 May 2008
Crystal Structure Of A Pumilio-Homology Domain
Overview
Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.
About this Structure
1M8Z is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ib3. Full crystallographic information is available from OCA.
Reference
Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708 Page seeded by OCA on Sat May 3 00:46:48 2008
