1m9o

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[[Image:1m9o.gif|left|200px]]
[[Image:1m9o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1m9o |SIZE=350|CAPTION= <scene name='initialview01'>1m9o</scene>
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The line below this paragraph, containing "STRUCTURE_1m9o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Nup475 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1m9o| PDB=1m9o | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9o OCA], [http://www.ebi.ac.uk/pdbsum/1m9o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m9o RCSB]</span>
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'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''
'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''
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[[Category: Berg, J M.]]
[[Category: Berg, J M.]]
[[Category: Worthington, M T.]]
[[Category: Worthington, M T.]]
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[[Category: cys3his type zinc finger]]
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[[Category: Cys3his type zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:47:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:13:14 2008''
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Revision as of 21:47, 2 May 2008

Image:1m9o.gif

Template:STRUCTURE 1m9o

NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11


Overview

Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.

About this Structure

1M9O is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557 Page seeded by OCA on Sat May 3 00:47:58 2008

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