1z7h

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Current revision (07:05, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1z7h' size='340' side='right'caption='[[1z7h]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1z7h' size='340' side='right'caption='[[1z7h]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tetani"_flugge_1886 "bacillus tetani" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tetX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1513 "Bacillus tetani" Flugge 1886])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7h OCA], [https://pdbe.org/1z7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7h RCSB], [https://www.ebi.ac.uk/pdbsum/1z7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7h OCA], [https://pdbe.org/1z7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7h RCSB], [https://www.ebi.ac.uk/pdbsum/1z7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus tetani flugge 1886]]
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[[Category: Clostridium tetani]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tentoxilysin]]
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[[Category: Breidenbach MA]]
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[[Category: Breidenbach, M A]]
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[[Category: Brunger AT]]
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[[Category: Brunger, A T]]
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[[Category: Hydrolase]]
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[[Category: Metalloprotease]]
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[[Category: Neurotransmission]]
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[[Category: Snare]]
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[[Category: Tent]]
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[[Category: Tetanus]]
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Current revision

2.3 Angstrom crystal structure of tetanus neurotoxin light chain

PDB ID 1z7h

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