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1zl7

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Current revision (07:10, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1zl7' size='340' side='right'caption='[[1zl7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1zl7' size='340' side='right'caption='[[1zl7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Botjr Botjr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZL7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZL7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1umv|1umv]], [[1zlb|1zlb]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zl7 OCA], [https://pdbe.org/1zl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zl7 RCSB], [https://www.ebi.ac.uk/pdbsum/1zl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zl7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zl7 OCA], [https://pdbe.org/1zl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zl7 RCSB], [https://www.ebi.ac.uk/pdbsum/1zl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zl7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA2A_BOTJR PA2A_BOTJR]] Snake venom phospholipase A2 (PLA2) that induces edema (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities. In addition, this enzyme shows bactericidal activity against E.coli and S.aureus. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:12167491</ref> <ref>PMID:15214498</ref>
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[https://www.uniprot.org/uniprot/PA2A_BOTJR PA2A_BOTJR] Snake venom phospholipase A2 (PLA2) that induces edema (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities. In addition, this enzyme shows bactericidal activity against E.coli and S.aureus. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:12167491</ref> <ref>PMID:15214498</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Botjr]]
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[[Category: Bothrops jararacussu]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arni, R K]]
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[[Category: Arni RK]]
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[[Category: Betzel, C]]
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[[Category: Betzel C]]
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[[Category: Cintra, A C]]
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[[Category: Cintra AC]]
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[[Category: Gabdoulkhakov, A]]
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[[Category: Gabdoulkhakov A]]
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[[Category: Genov, N]]
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[[Category: Genov N]]
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[[Category: Murakami, M T]]
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[[Category: Murakami MT]]
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[[Category: Asp49-pla2]]
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[[Category: Hydrolase]]
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[[Category: Snake venom]]
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Current revision

Crystal structure of catalytically-active phospholipase A2 with bound calcium

PDB ID 1zl7

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