1m9z

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[[Image:1m9z.gif|left|200px]]
[[Image:1m9z.gif|left|200px]]
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{{Structure
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|PDB= 1m9z |SIZE=350|CAPTION= <scene name='initialview01'>1m9z</scene>, resolution 1.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1m9z", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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{{STRUCTURE_1m9z| PDB=1m9z | SCENE= }}
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|RELATEDENTRY=[[1ktz|1KTZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m9z OCA], [http://www.ebi.ac.uk/pdbsum/1m9z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m9z RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN'''
'''CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN'''
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[[Category: Radaev, S.]]
[[Category: Radaev, S.]]
[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
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[[Category: three finger toxin fold]]
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[[Category: Three finger toxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:48:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:13:20 2008''
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Revision as of 21:48, 2 May 2008

Image:1m9z.gif

Template:STRUCTURE 1m9z

CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN


Overview

Transforming growth factor beta (TGF-beta) is involved in a wide range of biological functions including development, carcinogenesis, and immune regulation. Here we report the 1.1 A resolution crystal structure of human TGF-beta type II receptor ectodomain (TBRII). The overall structure of TBRII is similar to that of activin type II receptor ectodomain (ActRII) and bone morphogenic protein receptor type IA (BRIA). It displays a three-finger toxin fold with fingers formed by the beta strand pairs beta1-beta2, beta3-beta4, and beta5-beta6. The first finger in the TBRII is significantly longer than in ActRII and BRIA and folds tightly between the second finger and the C terminus. Surface charge distributions and hydrophobic patches predict potential TBRII binding sites.

About this Structure

1M9Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain., Boesen CC, Radaev S, Motyka SA, Patamawenu A, Sun PD, Structure. 2002 Jul;10(7):913-9. PMID:12121646 Page seeded by OCA on Sat May 3 00:48:35 2008

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