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1zsy

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Current revision (07:14, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1zsy' size='340' side='right'caption='[[1zsy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='1zsy' size='340' side='right'caption='[[1zsy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MECR, NBRF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trans-2-enoyl-CoA_reductase_(NADPH) Trans-2-enoyl-CoA reductase (NADPH)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.38 1.3.1.38] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsy OCA], [https://pdbe.org/1zsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zsy RCSB], [https://www.ebi.ac.uk/pdbsum/1zsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zsy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsy OCA], [https://pdbe.org/1zsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zsy RCSB], [https://www.ebi.ac.uk/pdbsum/1zsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zsy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MECR_HUMAN MECR_HUMAN]] Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.
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[https://www.uniprot.org/uniprot/MECR_HUMAN MECR_HUMAN] Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Johansson C]]
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[[Category: Johansson, C]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Shafqat N]]
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[[Category: Structural genomic]]
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[[Category: Smee C]]
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[[Category: Shafqat, N]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M]]
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[[Category: 2-enoyl thioester reductase]]
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[[Category: Medium-chain dehydrogenase/reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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Current revision

The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)

PDB ID 1zsy

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