1zx1

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Current revision (07:15, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1zx1' size='340' side='right'caption='[[1zx1]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='1zx1' size='340' side='right'caption='[[1zx1]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qr1|1qr1]], [[1qr2|1qr2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx1 OCA], [https://pdbe.org/1zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx1 OCA], [https://pdbe.org/1zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Gunther U]]
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[[Category: Gunther, U]]
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[[Category: Jansson A]]
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[[Category: Jansson, A]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K]]
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[[Category: Kerr D]]
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[[Category: Kerr, D]]
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[[Category: Knox R]]
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[[Category: Knox, R]]
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[[Category: Ludwig C]]
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[[Category: Ludwig, C]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Sundstrom M]]
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[[Category: Structural genomic]]
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[[Category: Walton R]]
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[[Category: Sundstrom, M]]
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[[Category: Wu X]]
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[[Category: Walton, R]]
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[[Category: Von Delft F]]
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[[Category: Wu, X]]
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[[Category: Dihydronicotinamide ribose]]
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[[Category: Electrondonor]]
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[[Category: Flavin-containing]]
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[[Category: Oxidoreductase]]
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[[Category: Quinone oxidoreductase 2]]
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[[Category: Reductions of quinone]]
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[[Category: Sgc]]
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Current revision

Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954

PDB ID 1zx1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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