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2ahw

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<StructureSection load='2ahw' size='340' side='right'caption='[[2ahw]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='2ahw' size='340' side='right'caption='[[2ahw]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ahw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ahw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ahu|2ahu]], [[2ahv|2ahv]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YdiF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahw OCA], [https://pdbe.org/2ahw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahw RCSB], [https://www.ebi.ac.uk/pdbsum/2ahw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahw ProSAT], [https://www.topsan.org/Proteins/BSGI/2ahw TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahw OCA], [https://pdbe.org/2ahw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahw RCSB], [https://www.ebi.ac.uk/pdbsum/2ahw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahw ProSAT], [https://www.topsan.org/Proteins/BSGI/2ahw TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/YDIF_ECO57 YDIF_ECO57]] CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA, propionyl-CoA, crotonoyl-CoA or butyryl-CoA as donors, with acetate as an acceptor. When acetyl-CoA is used as the donor, propionate, acetoacetate, butyrate, isobutyrate, and 4-hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E.coli.<ref>PMID:16253988</ref>
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[https://www.uniprot.org/uniprot/YDIF_ECO57 YDIF_ECO57] CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA, propionyl-CoA, crotonoyl-CoA or butyryl-CoA as donors, with acetate as an acceptor. When acetyl-CoA is used as the donor, propionate, acetoacetate, butyrate, isobutyrate, and 4-hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E.coli.<ref>PMID:16253988</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Eco57]]
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[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ajamian, E]]
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[[Category: Ajamian E]]
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[[Category: Structural genomic]]
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[[Category: Cylger M]]
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[[Category: Cylger, M]]
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[[Category: Fraser ME]]
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[[Category: Fraser, M E]]
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[[Category: Iannuzzi P]]
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[[Category: Iannuzzi, P]]
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[[Category: Kernaghan SD]]
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[[Category: Kernaghan, S D]]
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[[Category: Li Y]]
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[[Category: Li, Y]]
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[[Category: Matte A]]
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[[Category: Matte, A]]
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[[Category: Rangarajan ES]]
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[[Category: Rangarajan, E S]]
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[[Category: Bsgi]]
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[[Category: Coa transferase]]
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[[Category: Glutamyl thioester]]
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[[Category: Transferase]]
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[[Category: Ydif]]
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Revision as of 07:24, 23 August 2023

Crystal Structure of Acyl-CoA transferase from E. coli O157:H7 (YdiF)-thioester complex with CoA- 2

PDB ID 2ahw

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