2axr

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<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zr6|1zr6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [https://pdbe.org/2axr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [https://www.ebi.ac.uk/pdbsum/2axr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [https://pdbe.org/2axr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [https://www.ebi.ac.uk/pdbsum/2axr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GOOX_SARSR GOOX_SARSR] Catalyzes the selective oxidation of C1 hydroxyl moieties on mono- and disaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Glucooligosaccharide oxidase is able to oxidize the monosaccharide D-glucose as well as the disaccharides maltose, cellobiose, and lactose. In addition, it shows high selectivity for cello- and maltooligosaccharides, indicating that glucooligosaccharide oxidase prefers oligosaccharides with a beta-D-glucosyl unit on the reducing end and additional sugar units linked by alpha- or beta-1,4 glucosidic bonds.<ref>PMID:16332885</ref> <ref>PMID:1764476</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 34717]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, C H]]
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[[Category: Sarocladium strictum]]
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[[Category: Lai, W L]]
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[[Category: Huang C-H]]
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[[Category: Liaw, S H]]
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[[Category: Lai W-L]]
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[[Category: Tsai, Y C]]
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[[Category: Liaw S-H]]
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[[Category: Vasella, A]]
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[[Category: Tsai Y-C]]
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[[Category: Alpha+beta]]
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[[Category: Vasella A]]
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[[Category: Covalent flavoenzyme]]
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[[Category: Oxidoreductase]]
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Revision as of 07:31, 23 August 2023

Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD

PDB ID 2axr

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