2ew1

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Current revision (07:40, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2ew1' size='340' side='right'caption='[[2ew1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2ew1' size='340' side='right'caption='[[2ew1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ew1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ew1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew1 OCA], [https://pdbe.org/2ew1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew1 OCA], [https://pdbe.org/2ew1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAB30_HUMAN RAB30_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
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[https://www.uniprot.org/uniprot/RAB30_HUMAN RAB30_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Ismail, S]]
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[[Category: Ismail S]]
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[[Category: Park, H W]]
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[[Category: Park HW]]
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[[Category: Structural genomic]]
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[[Category: Shen Y]]
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[[Category: Shen, Y]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: G-protein]]
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[[Category: Gtp analogue]]
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[[Category: Rab]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Rab30 in complex with a GTP analogue

PDB ID 2ew1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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