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2f44

From Proteopedia

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Current revision (07:42, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2f44' size='340' side='right'caption='[[2f44]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2f44' size='340' side='right'caption='[[2f44]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f44]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F44 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f44]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F44 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f3n|2f3n]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Shank3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f44 OCA], [https://pdbe.org/2f44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f44 RCSB], [https://www.ebi.ac.uk/pdbsum/2f44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f44 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f44 OCA], [https://pdbe.org/2f44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f44 RCSB], [https://www.ebi.ac.uk/pdbsum/2f44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f44 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SHAN3_RAT SHAN3_RAT]] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
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[https://www.uniprot.org/uniprot/SHAN3_RAT SHAN3_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baron, M K]]
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[[Category: Rattus norvegicus]]
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[[Category: Bowie, J U]]
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[[Category: Baron MK]]
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[[Category: Faham, S]]
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[[Category: Bowie JU]]
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[[Category: Post-synaptic density]]
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[[Category: Faham S]]
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[[Category: Sam domain]]
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[[Category: Scaffolding protein]]
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[[Category: Shank]]
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[[Category: Structural protein]]
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[[Category: Zinc]]
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Current revision

Crystal Structure of the Zinc-bound Shank SAM domain

PDB ID 2f44

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OCA

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