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1mf8

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(New page: 200px<br /> <applet load="1mf8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mf8, resolution 3.1&Aring;" /> '''Crystal Structure of...)
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Revision as of 16:04, 12 November 2007

Image:1mf8.gif

1mf8, resolution 3.1Å

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Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Contents

Overview

Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein, phosphatase, is an important participant in signaling pathways that, activate T cells. It is the target of the immunosuppressive drugs, cyclosporin A (CsA) and FK506. These drugs bind proteins known as, cyclophilin (Cyp) and FK506-binding protein, respectively, and the, drug-protein complexes in turn inhibit Cn. We report the crystal structure, of a Cyp/CsA/Cn ternary complex, determined to a resolution of 3.1 A., Residues 3-9 of CsA, particularly N-methyl leucines 4 and 6, and Trp-121, of Cyp form a composite surface for interaction with Cn. The hydrophobic, interface buries two hydrogen bonds. The structure accounts clearly for, the effects of mutations in Cn on CsA-resistance and for the way, modifications of CsA alter immunosuppressive activity.

Disease

Known diseases associated with this structure: Cornea plana congenita, recessive OMIM:[603288], Myotonic dystrophy, type 2 OMIM:[116955]

About this Structure

1MF8 is a Protein complex structure of sequences from Homo sapiens with CA and PO4 as ligands. Active as Phosphoprotein phosphatase, with EC number 3.1.3.16 Full crystallographic information is available from OCA.

Reference

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin., Jin L, Harrison SC, Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13522-6. Epub 2002 Sep 30. PMID:12357034

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