2y46

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Current revision (08:08, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2y46' size='340' side='right'caption='[[2y46]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='2y46' size='340' side='right'caption='[[2y46]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y46]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/'micromonospora_griseorubida' 'micromonospora griseorubida']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y46 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y46]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_griseorubida Micromonospora griseorubida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y46 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MIV:MYCINAMICIN+IV'>MIV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y4h|2y4h]], [[2y5n|2y5n]], [[2y5z|2y5z]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MIV:MYCINAMICIN+IV'>MIV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y46 OCA], [https://pdbe.org/2y46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y46 RCSB], [https://www.ebi.ac.uk/pdbsum/2y46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y46 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y46 OCA], [https://pdbe.org/2y46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y46 RCSB], [https://www.ebi.ac.uk/pdbsum/2y46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y46 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYCG_MICGR MYCG_MICGR] Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes consecutive hydroxylation (at C14) and epoxidation (at C12-C13) reactions with mycinamicin IV as initial substrate, leading to mycinamicin II. These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme.<ref>PMID:18804032</ref> <ref>PMID:22547618</ref> <ref>PMID:7808395</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micromonospora griseorubida]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kells, P M]]
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[[Category: Micromonospora griseorubida]]
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[[Category: Li, S]]
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[[Category: Kells PM]]
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[[Category: Podust, L M]]
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[[Category: Li S]]
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[[Category: Sherman, D H]]
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[[Category: Podust LM]]
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[[Category: Mycinamicin biosynthesis]]
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[[Category: Sherman DH]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group

PDB ID 2y46

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