2y7j

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Current revision (08:09, 23 August 2023) (edit) (undo)
 
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<StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase_kinase Phosphorylase kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.19 2.7.11.19] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [https://pdbe.org/2y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [https://www.ebi.ac.uk/pdbsum/2y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [https://pdbe.org/2y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [https://www.ebi.ac.uk/pdbsum/2y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7j ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref>
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[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphorylase kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berridge G]]
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[[Category: Berridge, G]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Brenner B]]
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[[Category: Brenner, B]]
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[[Category: Burgess-Brown N]]
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[[Category: Burgess-Brown, N]]
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[[Category: Che KH]]
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[[Category: Che, K H]]
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[[Category: Edwards AM]]
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[[Category: Delft, F von]]
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[[Category: Elkins JM]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov O]]
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[[Category: Elkins, J M]]
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[[Category: Knapp S]]
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[[Category: Fedorov, O]]
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[[Category: Krojer T]]
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[[Category: Knapp, S]]
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[[Category: Muniz JRC]]
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[[Category: Krojer, T]]
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[[Category: Rellos P]]
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[[Category: Muniz, J R.C]]
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[[Category: Savitsky P]]
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[[Category: Rellos, P]]
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[[Category: Shrestha A]]
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[[Category: Savitsky, P]]
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[[Category: Vollmar M]]
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[[Category: Shrestha, A]]
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[[Category: Wang J]]
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[[Category: Vollmar, M]]
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[[Category: Weigelt J]]
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[[Category: Wang, J]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Transferase]]
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Current revision

Structure of human phosphorylase kinase, gamma 2

PDB ID 2y7j

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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