1mco

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[[Image:1mco.jpg|left|200px]]
[[Image:1mco.jpg|left|200px]]
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{{Structure
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|PDB= 1mco |SIZE=350|CAPTION= <scene name='initialview01'>1mco</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1mco", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GUP:BETA-L-GULOPYRANOSIDE'>GUP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
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{{STRUCTURE_1mco| PDB=1mco | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mco OCA], [http://www.ebi.ac.uk/pdbsum/1mco PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mco RCSB]</span>
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'''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION'''
'''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION'''
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[[Category: Edmundson, A B.]]
[[Category: Edmundson, A B.]]
[[Category: Guddat, L W.]]
[[Category: Guddat, L W.]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:53:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:14:26 2008''
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Revision as of 21:53, 2 May 2008

Image:1mco.jpg

Template:STRUCTURE 1mco

THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION


Overview

X-ray analysis at 3.2-A resolution revealed that the Mcg IgG1 (lambda chain) immunoglobulin is a compact T-shaped molecule. Because of the hinge deletion, the Fc fragment lobe is pulled tightly upward into the junction of the Fab arms. Along the molecular twofold axis, the Fab arms are joined by an interchain disulfide bond between the two light chains. The antigen combining sites consist of large irregular cavities at the tips of the Fab regions. Potential complement (C1q) binding sites on Fc are sterically shielded by the Fab arms, but putative attachment sites are accessible for docking with the FcRI receptor on human monocytes and with protein A of Staphylococcus aureus.

About this Structure

1MCO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:8483943 Page seeded by OCA on Sat May 3 00:53:34 2008

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