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5i59

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Current revision (08:23, 23 August 2023) (edit) (undo)
 
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<StructureSection load='5i59' size='340' side='right'caption='[[5i59]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5i59' size='340' side='right'caption='[[5i59]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I59 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I59 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=67Q:5-({[(3,4-DIFLUOROPHENYL)SULFONYL]AMINO}METHYL)-6-METHYL-N-[(2-METHYL-4H-1LAMBDA~4~,3-THIAZOL-5-YL)METHYL]PYRAZINE-2-CARBOXAMIDE'>67Q</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i57|5i57]], [[5i56|5i56]], [[5i58|5i58]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=67Q:5-({[(3,4-DIFLUOROPHENYL)SULFONYL]AMINO}METHYL)-6-METHYL-N-[(2-METHYL-4H-1LAMBDA~4~,3-THIAZOL-5-YL)METHYL]PYRAZINE-2-CARBOXAMIDE'>67Q</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grin1, Nmdar1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Grin2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i59 OCA], [https://pdbe.org/5i59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i59 RCSB], [https://www.ebi.ac.uk/pdbsum/5i59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i59 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i59 OCA], [http://pdbe.org/5i59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i59 RCSB], [http://www.ebi.ac.uk/pdbsum/5i59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i59 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
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[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hansen, K B]]
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[[Category: Rattus norvegicus]]
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[[Category: Mou, T C]]
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[[Category: Hansen KB]]
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[[Category: Sprang, S R]]
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[[Category: Mou T-C]]
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[[Category: Antagonist]]
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[[Category: Sprang SR]]
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[[Category: Nmda receptor]]
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[[Category: Receptor]]
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[[Category: Transport protein]]
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Current revision

Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007

PDB ID 5i59

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OCA

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