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5i5c

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Current revision (08:23, 23 August 2023) (edit) (undo)
 
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<StructureSection load='5i5c' size='340' side='right'caption='[[5i5c]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5i5c' size='340' side='right'caption='[[5i5c]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i5c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I5C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALO:ALLO-THREONINE'>ALO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALO:ALLO-THREONINE'>ALO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i5a|5i5a]], [[5i5b|5i5b]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5c OCA], [https://pdbe.org/5i5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i5c RCSB], [https://www.ebi.ac.uk/pdbsum/5i5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5c OCA], [http://pdbe.org/5i5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i5c RCSB], [http://www.ebi.ac.uk/pdbsum/5i5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5c ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/K1A_STIHL K1A_STIHL]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
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[https://www.uniprot.org/uniprot/K1A_STIHL K1A_STIHL] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bezanilla, F]]
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[[Category: Stichodactyla helianthus]]
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[[Category: Dang, B]]
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[[Category: Bezanilla F]]
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[[Category: Kent, S B.H]]
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[[Category: Dang B]]
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[[Category: Kubota, T]]
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[[Category: Kent SBH]]
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[[Category: Manda, K l]]
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[[Category: Kubota T]]
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[[Category: Roux, B]]
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[[Category: Manda Kl]]
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[[Category: Shen, R]]
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[[Category: Roux B]]
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[[Category: Allo-thr31-shk]]
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[[Category: Shen R]]
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[[Category: Toxin]]
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Current revision

X-ray crystal structure of allo-Thr31-ShK

PDB ID 5i5c

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