5i5o

From Proteopedia

(Difference between revisions)

Current revision

Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neutral pH.

Structural highlights

5i5o is a 2 chain structure with sequence from Thogoto thogotovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.682Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ML_THOGV Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.^[1] ^[2] ^[3]

Publication Abstract from PubMed

The matrix proteins of orthomyxoviruses, including influenza virus, infectious salmon anemia virus and Thogoto virus, play crucial roles in essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes are not fully understood. Currently, only the structure and function of the matrix protein from influenza virus have been studied. Here, we present the crystal structures of the N-terminal domain of matrix protein from Thogoto virus at pH 7.0 and 4.5. By analyzing the structures, we identified the conformational changes of monomers and dimers in different pH conditions, mainly caused by two flexible loops, L3 and L5. We suggest these structural deviations would reflect the basis of viral capsid assembly or disassembly.

Conformational changes of matrix protein from Thogoto virus at different pH implicate the mechanism of viral assembly and uncoating.,Yang M, Feng F, Liu Y, Wang H, Yang Z, Hou W, Liang H J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000551. PMID:27411929^[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jennings S, Martínez-Sobrido L, García-Sastre A, Weber F, Kochs G. Thogoto virus ML protein suppresses IRF3 function. Virology. 2005 Jan 5;331(1):63-72. PMID:15582653 doi:10.1016/j.virol.2004.10.015
↑ Vogt C, Preuss E, Mayer D, Weber F, Schwemmle M, Kochs G. The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB. J Virol. 2008 Nov;82(22):11446-53. PMID:18768974 doi:10.1128/JVI.01284-08
↑ Buettner N, Vogt C, Martínez-Sobrido L, Weber F, Waibler Z, Kochs G. Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor. J Gen Virol. 2010 Jan;91(Pt 1):220-7. PMID:19812269 doi:10.1099/vir.0.015172-0
↑ Yang M, Feng F, Liu Y, Wang H, Yang Z, Hou W, Liang H. Conformational changes of matrix protein from Thogoto virus at different pH implicate the mechanism of viral assembly and uncoating. J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000551. PMID:27411929 doi:http://dx.doi.org/10.1099/jgv.0.000551

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5i5o"

Categories: Large Structures | Thogoto thogotovirus | Liang H | Liu Y | Yang M

@@ Line 3: / Line 3: @@
 <StructureSection load='5i5o' size='340' side='right'caption='[[5i5o]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5i5o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I5O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5i5o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_thogotovirus Thogoto thogotovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I5O FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i5n|5i5n]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.682&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5o OCA], [http://pdbe.org/5i5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i5o RCSB], [http://www.ebi.ac.uk/pdbsum/5i5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5o ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5o OCA], [https://pdbe.org/5i5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i5o RCSB], [https://www.ebi.ac.uk/pdbsum/5i5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5o ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ML_THOGV ML_THOGV] Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.<ref>PMID:15582653</ref> <ref>PMID:18768974</ref> <ref>PMID:19812269</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Liang, H]]
+[[Category: Thogoto thogotovirus]]
-[[Category: Liu, Y]]
+[[Category: Liang H]]
-[[Category: Yang, M]]
+[[Category: Liu Y]]
-[[Category: Viral protein]]
+[[Category: Yang M]]

5i5o

From Proteopedia

Current revision

Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neutral pH.

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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