Phospholipase D

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== Structural highlights ==
== Structural highlights ==
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere.
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==3D structures of phospholipase D==
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[[Phospholipase D 3D structures]]
</StructureSection>
</StructureSection>

Revision as of 08:38, 28 August 2023

Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y)

Drag the structure with the mouse to rotate

3D structures of phospholipase D

Updated on 28-August-2023

6u8z – hPLD1 catalytic domain 330-500, 643-1074 – human
6ohr – hPLD1 catalytic domain + inhibitor
6ohm, 6oho – hPLD2 catalytic domain 294-933
6ohq, 6ohs, 6ohp – hPLD2 catalytic domain + inhibitor
4rw3 – bsPLD – brown spider
4rw5 – bsPLD (mutant)
3rlg, 3rlh – PLD (mutant) – Loxosceles intemedia
4q6x – PLD – cave spider
2ze4, 1v0r, 1v0s, 1f0i – SaPLD – Streptomyces antibioticus
7jrb – SaPLD (mutant)
1v0v, 1v0w – SaPLD + phosphite
1v0y – SaPLD + phosphatidylcholine derivative
2ze9 – SaPLD (mutant) + phosphatidylcholine
1v0t, 1v0u – SaPLD + glycerophosphate
7jrc – SaPLD (mutant) + phosphate
7js5, 7js7 – SaPLD (mutant) + inositol phosphate
7jru, 7jrv, 7jrw – SaPLD (mutant) + phosphatidic acid
6kz9 – AtPLD a 1 – Arabidopsis thaliana
6kz8 – AtPLD a 1 + phosphatidic acid

References

  1. ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
  2. ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
  3. ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003

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