1mel

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[[Image:1mel.jpg|left|200px]]
[[Image:1mel.jpg|left|200px]]
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{{Structure
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|PDB= 1mel |SIZE=350|CAPTION= <scene name='initialview01'>1mel</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1mel", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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|GENE= ANTIBODY VH FRAGMENT CAB-LYS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9838 Camelus dromedarius]), ANTIBODY VH FRAGMENT CAB-LYS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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{{STRUCTURE_1mel| PDB=1mel | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mel OCA], [http://www.ebi.ac.uk/pdbsum/1mel PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mel RCSB]</span>
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'''CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME'''
'''CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME'''
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[[Category: Transue, T R.]]
[[Category: Transue, T R.]]
[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
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[[Category: camel single-domain anti-lysozyme]]
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[[Category: Camel single-domain anti-lysozyme]]
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[[Category: complex (antibody/antigen)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:56:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:07 2008''
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Revision as of 21:56, 2 May 2008

Image:1mel.jpg


PDB ID 1mel

Drag the structure with the mouse to rotate
1mel, resolution 2.50Å ()
Gene: ANTIBODY VH FRAGMENT CAB-LYS3 (Camelus dromedarius), ANTIBODY VH FRAGMENT CAB-LYS3 (Gallus gallus)
Activity: Lysozyme, with EC number 3.2.1.17
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME


Overview

The Camelidae is the only taxonomic family known to possess functional heavy-chain antibodies, lacking light chains. We report here the 2.5 A resolution crystal structure of a camel VH in complex with its antigen, lysozyme. Compared to human and mouse VH domains, there are no major backbone rearrangements in the VH framework. However, the architecture of the region of VH that interacts with a VL in a conventional FV is different from any previously seen. Moreover, the CDR1 region, although in sequence homologous to human CDR1, deviates fundamentally from the canonical structure. Additionally, one half of the CDR3 contacts the VH region which in conventional immunoglobulins interacts with a VL whereas the other half protrudes from the antigen binding site and penetrates deeply into the active site of lysozyme.

About this Structure

1MEL is a Single protein structure of sequence from Camelus dromedarius and Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme., Desmyter A, Transue TR, Ghahroudi MA, Thi MH, Poortmans F, Hamers R, Muyldermans S, Wyns L, Nat Struct Biol. 1996 Sep;3(9):803-11. PMID:8784355 Page seeded by OCA on Sat May 3 00:56:41 2008

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