8c1s

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'''Unreleased structure'''
 
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The entry 8c1s is ON HOLD until Paper Publication
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==Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2==
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<StructureSection load='8c1s' size='340' side='right'caption='[[8c1s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Zhang, D., Ivica, J., Krieger, J.M., Ho, H., Yamashita, K., Cais, O., Greger, I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c1s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C1S FirstGlance]. <br>
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Description: Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
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[[Category: Ho, H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c1s OCA], [https://pdbe.org/8c1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c1s RCSB], [https://www.ebi.ac.uk/pdbsum/8c1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c1s ProSAT]</span></td></tr>
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[[Category: Cais, O]]
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</table>
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[[Category: Krieger, J.M]]
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== Function ==
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[[Category: Yamashita, K]]
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[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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[[Category: Zhang, D]]
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== References ==
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[[Category: Ivica, J]]
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<references/>
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[[Category: Greger, I]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Cais O]]
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[[Category: Greger I]]
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[[Category: Ho H]]
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[[Category: Ivica J]]
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[[Category: Krieger JM]]
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[[Category: Yamashita K]]
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[[Category: Zhang D]]

Revision as of 09:06, 30 August 2023

Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2

PDB ID 8c1s

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OCA

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