8e7t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL protease inactive mutant C148A== | |
| - | + | <StructureSection load='8e7t' size='340' side='right'caption='[[8e7t]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e7t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E7T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e7t OCA], [https://pdbe.org/8e7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e7t RCSB], [https://www.ebi.ac.uk/pdbsum/8e7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e7t ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Shaqra | + | == Function == |
| + | [https://www.uniprot.org/uniprot/W6A941_MERS W6A941_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
| + | [[Category: Schiffer CA]] | ||
| + | [[Category: Shaqra AM]] | ||
| + | [[Category: Zvornicanin SN]] | ||
Current revision
Crystal structure of Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL protease inactive mutant C148A
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