8p3t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1== | |
| - | + | <StructureSection load='8p3t' size='340' side='right'caption='[[8p3t]], [[Resolution|resolution]] 3.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p3t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P3T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p3t OCA], [https://pdbe.org/8p3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p3t RCSB], [https://www.ebi.ac.uk/pdbsum/8p3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p3t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIA1_RAT GRIA1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:16793768</ref> <ref>PMID:19265014</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Greger I]] | ||
| + | [[Category: Krieger J]] | ||
| + | [[Category: Yamashita K]] | ||
| + | [[Category: Zhang D]] | ||
Revision as of 09:17, 30 August 2023
Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1
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