1mf8

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[[Image:1mf8.gif|left|200px]]
[[Image:1mf8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mf8 |SIZE=350|CAPTION= <scene name='initialview01'>1mf8</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1mf8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1mf8| PDB=1mf8 | SCENE= }}
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|RELATEDENTRY=[[1aui|1AUI]], [[2rma|2RMA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf8 OCA], [http://www.ebi.ac.uk/pdbsum/1mf8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mf8 RCSB]</span>
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}}
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'''Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin'''
'''Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Jin, L.]]
[[Category: Jin, L.]]
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[[Category: immunosuppressant]]
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[[Category: Immunosuppressant]]
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[[Category: protein-drug complex]]
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[[Category: Protein-drug complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:57:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:24 2008''
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Revision as of 21:57, 2 May 2008

Image:1mf8.gif

Template:STRUCTURE 1mf8

Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin


Overview

Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding protein, respectively, and the drug-protein complexes in turn inhibit Cn. We report the crystal structure of a Cyp/CsA/Cn ternary complex, determined to a resolution of 3.1 A. Residues 3-9 of CsA, particularly N-methyl leucines 4 and 6, and Trp-121 of Cyp form a composite surface for interaction with Cn. The hydrophobic interface buries two hydrogen bonds. The structure accounts clearly for the effects of mutations in Cn on CsA-resistance and for the way modifications of CsA alter immunosuppressive activity.

About this Structure

1MF8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin., Jin L, Harrison SC, Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13522-6. Epub 2002 Sep 30. PMID:12357034 Page seeded by OCA on Sat May 3 00:57:47 2008

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